Alice Howland, happily married with three grown children, is a renowned linguistics professor who starts to forget words. When she receives a devastating diagnosis, Alice and her family find their bonds tested.
In the 1940s in the small town of Jupiter Hollow, two sets of identical twins are born in the same hospital on the same night. One set to a poor local family and the other to a rich family just passing through. The dizzy nurse on duty accidentally mixes the twins unbeknown to the parents. Our story flashes forward to the 1980s where the mismatched sets of twins are about to cross paths.
Carla and Marco are manic-depressive poets whose art is fueled by their emotional extremes. When they go off their meds, they end up in the same psychiatric hospital. As the chemistry between them stirs up their emotions, it intensifies their mania. Despite doctors’ and parents’ attempts to separate them, they pursue their beautiful but destructive romance which swings them from fantastical manic highs to suicidal depressive lows, until they have to choose between sanity and love.
When Elizabeth returns to her mother’s home after her marriage breaks up, she recreates her imaginary childhood friend, Fred, to escape from the trauma of losing her husband and her job. In between the chaos and mayhem that Fred creates, Elizabeth attempts to win back her husband and return to normality.
When a humorous script-reader in her New York apartment sees an ad in the Saturday Review of Literature for a bookstore in London that does mail order, she begins a very special correspondence and friendship with Frank Doel, the bookseller who works at Marks & Co., 84 Charing Cross Road.
Thrown together under incredible circumstances, two strangers must discover courage and strength when they begin a journey across the treacherous African desert! Equipped only with their wits and the expertise of a native bushman who befriends them, they are determined to triumph over impossible odds and reach their destination. But along the way, the trio face a primitive desert wilderness.