Test pilot Tuck Pendleton volunteers to test a special vessel for a miniaturization experiment. Accidentally injected into a neurotic hypochondriac, Jack Putter, Tuck must convince Jack to find his ex-girlfriend, Lydia Maxwell, to help him extract Tuck and his ship and re-enlarge them before his oxygen runs out.
Charlie’s ex-wife disappears, and he goes to where she grew up–a rural town in the midwest–to look for her. But, surprisingly, nobody knows about her or any of her many relatives, the Newmans. He meets aliens; but when he contacts the FBI, they don’t believe him. He tells his story to a tabloid; and suddenly, he is chased by the aliens.